I’m no fan of the way Google Chrome manages my plethora of extension. – Just too many clicks, too many switching windows.
A great solution to this is Extensions Manager (aka Switcher) from cmrd.Kaash. Running from the toolbar, click it to a categorised list of all your extensions and with one click you can enable and disable them which is fantastic for when you developing and designing and doing normal browsing (I’m not a huge fan of Chromes Profile options either).
Give it a try at the Google Web Store.